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Cycloserine

Topic Contents

Cycloserine

Drug Information

Cycloserine is a broad-spectrum antibiotic used to treat tuberculosis. It is used rarely for treating noninfectious diseases.

Common brand names:

Seromycin

Summary of Interactions with Vitamins, Herbs, & Foods

Types of interactions: Beneficial Adverse Check

Replenish Depleted Nutrients

  • Vitamin K

    Many antibiotics taken by mouth, including cycloserine, may kill friendly bacteria in the large intestine that produce vitamin K.1 With short-term (a few weeks or less) antibiotic use, the actions on vitamin K are usually mild and cause no problems. After antibiotic therapy is completed, vitamin K activity returns to normal.

  • Calcium

    Cycloserine may interfere with calcium and magnesium absorption.2 The clinical significance of these interactions is unclear.

    Cycloserine may interfere with the absorption and/or activity of folic acid, vitamin B6, and vitamin B12.3 , 4 The clinical importance of this interaction is unclear.

    The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
  • Folic Acid

    Cycloserine may interfere with calcium and magnesium absorption.5 The clinical significance of these interactions is unclear.

    Cycloserine may interfere with the absorption and/or activity of folic acid, vitamin B6, and vitamin B12.6 , 7 The clinical importance of this interaction is unclear.

    The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
  • Magnesium

    Cycloserine may interfere with calcium and magnesium absorption.8 The clinical significance of these interactions is unclear.

    Cycloserine may interfere with the absorption and/or activity of folic acid, vitamin B6, and vitamin B12.9 , 10 The clinical importance of this interaction is unclear.

    The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
  • Vitamin B12

    Cycloserine may interfere with calcium and magnesium absorption.11 The clinical significance of these interactions is unclear.

    Cycloserine may interfere with the absorption and/or activity of folic acid, vitamin B6, and vitamin B12.12 , 13 The clinical importance of this interaction is unclear.

    The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
  • Vitamin B6

    Cycloserine may interfere with calcium and magnesium absorption.14 The clinical significance of these interactions is unclear.

    Cycloserine may interfere with the absorption and/or activity of folic acid, vitamin B6, and vitamin B12.15 , 16 The clinical importance of this interaction is unclear.

    The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.

Reduce Side Effects

  • none

Support Medicine

  • none

Reduces Effectiveness

  • none

Potential Negative Interaction

  • none

Explanation Required 

  • none

The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.

References

1. Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 86.

2. Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 86.

3. Roe D, Campbell T, eds. Drugs and Nutrients: The Interactive Effects. New York: Marcel Decker, 1984, 288–9, 505–23.

4. Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 86.

5. Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 86.

6. Roe D, Campbell T, eds. Drugs and Nutrients: The Interactive Effects. New York: Marcel Decker, 1984, 288–9, 505–23.

7. Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 86.

8. Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 86.

9. Roe D, Campbell T, eds. Drugs and Nutrients: The Interactive Effects. New York: Marcel Decker, 1984, 288–9, 505–23.

10. Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 86.

11. Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 86.

12. Roe D, Campbell T, eds. Drugs and Nutrients: The Interactive Effects. New York: Marcel Decker, 1984, 288–9, 505–23.

13. Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 86.

14. Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 86.

15. Roe D, Campbell T, eds. Drugs and Nutrients: The Interactive Effects. New York: Marcel Decker, 1984, 288–9, 505–23.

16. Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 86.

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