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Gemifloxacin

Topic Contents

Gemifloxacin

Drug Information

Gemifloxacin is used to treat bacterial infections, such as chronic bronchitis and mild to moderate pneumonia.

Common brand names:

Factive

Summary of Interactions with Vitamins, Herbs, & Foods

Types of interactions: Beneficial Adverse Check

Replenish Depleted Nutrients

  • none

Reduce Side Effects

  • none

Support Medicine

  • none

Reduces Effectiveness

  • Calcium

    A recent study showed that taking calcium carbonate and gemifloxacin at the same time results in a significant reduction in blood levels of the drug.1 Consequently, gemifloxacin and calcium supplements should not be taken at the same time.

  • Iron

    A review of interactions involving quinolone antibiotics indicated that supplements containing iron, when taken at the same time as gemifloxacin, might reduce absorption of the drug up to 50%.2 Consequently, gemifloxacin and supplements containing iron should not be taken at the same time.

  • Magnesium

    One study showed that taking an antacid containing magnesium and aluminum ten minutes before gemifloxacin results in an 85% reduction in the absorption of the drug.3 Consequently, gemifloxacin and supplements containing magnesium should not be taken at the same time.

Potential Negative Interaction

  • none

Explanation Required 

  • none

The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.

References

1. Allen A, Vousden M, Porter A, Lewis A. Effect of Maalox on the bioavailability of oral gemifloxacin in healthy volunteers. Chemotherapy 1999;45:504–11.

2. Lode H. Evidence of different profiles of side effects and drug-drug interactions among the quinolones—the pharmacokinetic standpoint. Chemotherapy 2001;47 Suppl 3:24–31; discussion 44–8.

3. Pletz MW, Petzold P, Allen, et al. Effect of calcium carbonate on bioavailability of orally administered gemifloxacin. Antimicrob Agents Chemother 2003;47:2158–60.

This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. How this information was developed to help you make better health decisions.

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