Important It is possible that the main title of the report CADASIL is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
Synonyms: Hereditary Multi-Infarct Dementia Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy
CADASIL is a rare genetic disorder that causes multiple strokes in adults, even young adults, often without cardiovascular risk factors. CADASIL often progresses to cause cognitive impairment and dementia. The symptoms of CADASIL result from damage of various small blood vessels, especially those within the brain. The age of onset, severity, specific symptoms and disease progression varies greatly from one person to another, even among members of the same family. CADASIL is an acronym that stands for:
(C)erebral - relating to the brain (A)utosomal (D)ominant - a form of inheritance in which one copy of an abnormal gene is necessary for the development of a disorder.
(A)rteriopathy - disease of the small arteries (blood vessels that carry blood away from the heart).
(S)ubcortical - relating to a specific area of the deep brain that is involved in higher functioning (e.g., voluntary movements, reasoning, memory).
(I)nfarcts - tissue loss in the brain caused by lack of oxygen to the brain, which occurs when blood flow in the small arteries is blocked or abnormal.
(L)eukoencephalopathy - destruction of the myelin, an oily substance that covers and protects nerve fibers in the central nervous system.
United Leukodystrophy Foundation 2304 Highland Drive Sycamore, IL 60718 Fax: (815)895-2432 Tel: (800)728-5483 Email: email@example.com Internet: http://www.ulf.org/
NIH/National Institute of Neurological Disorders and Stroke P.O. Box 5801 Bethesda, MD 20824 Tel: (301)496-5751 Fax: (301)402-2186 Tel: (800)352-9424 TDD: (301)468-5981 Email: firstname.lastname@example.org Internet: http://www.ninds.nih.gov/
CADASIL-Together We Have Hope 3605 Monument Drive Round Rock, TX 78681 USA Tel: (512)255-0209 Fax: (512)255-0209 Tel: (877)519-4673 Email: email@example.com Internet: http://www.cadasilfoundation.org
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It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report
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Last Updated: 11/9/2009 Copyright 2009 National Organization for Rare Disorders, Inc.
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