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Drug Guide - Multum

acetaminophen (injection)

acetaminophen (injection)

Pronunciation: a SEET a MIN oh FEN

Brand: Ofirmev

What is the most important information I should know about acetaminophen injection?

Multum donot

You should not use this medication if you are allergic to acetaminophen, or if you have severe liver disease.

Multum donot

Do not use more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death.

Multum emt

Before using acetaminophen injection, tell your doctor if you have a history of alcoholism or liver disease (especially cirrhosis), or if you drink more than 3 alcoholic beverages per day.

Multum noalcohol

Avoid drinking alcohol. It may increase your risk of liver damage while using acetaminophen injection.

Multum emt

Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP.

What is acetaminophen injection?

Acetaminophen is a pain reliever and a fever reducer.

Acetaminophen injection is used to treat pain and to reduce fever. Acetaminophen injection is sometimes given with opioid (sometimes called narcotic) pain medication to treat moderate to severe pain.

Acetaminophen injection may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before using acetaminophen injection?

Multum donot

You should not use this medication if you are allergic to acetaminophen, or if you have severe liver disease.

Multum emt

Before using acetaminophen injection, tell your doctor if you have ever had alcoholic liver disease (cirrhosis) or if you drink more than 3 alcoholic beverages per day.

To make sure you can safely use this medication, tell your doctor if you have any of these other conditions:

  • kidney disease; or
  • if you are malnourished.
Multum nopreg

FDA pregnancy category C. Your doctor will determine whether acetaminophen is safe for you to use during pregnancy. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

Multum nobrfeed

Acetaminophen can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Multum nochild

Acetaminophen injection should not be given to a child younger than 2 years old.

How is acetaminophen injection given?

Acetaminophen injection is injected into a vein through an IV. You may be shown how to use an IV at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine.

Multum donot

Do not use more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death.

Acetaminophen injection is usually given once every 4 to 6 hours. Follow your doctor's dosing instructions very carefully.

Each single use vial (bottle) of this medicine is for one use only. Throw away after one use, even if there is still some medicine left in it after injecting your dose.

Multum rt

Store at room temperature away from heat and moisture. Do not refrigerate or freeze.

You must use the medication within 6 hours after opening a vial.

What happens if I miss a dose?

Since acetaminophen is used as needed, you may not be on a dosing schedule. If you are using the medication regularly, use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

Do not use acetaminophen injection more often than every 4 hours.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of acetaminophen can be fatal.

The first signs of an acetaminophen overdose include loss of appetite, nausea, vomiting, stomach pain, sweating, and confusion or weakness. Later symptoms may include pain in your upper stomach, dark urine, and yellowing of your skin or the whites of your eyes.

Overdose symptoms may also include hunger with irritability, fast heart rate, tremors, feeling jittery, trouble concentrating, easy bruising, unusual bleeding, or purple or red pinpoint spots under your skin.

What should I avoid while using acetaminophen injection?

Multum donot

Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP.

Multum noalcohol

Avoid drinking alcohol. It may increase your risk of liver damage while taking acetaminophen.

What are the possible side effects of acetaminophen injection?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Multum donot

Stop taking this medication and call your doctor at once if you have a serious side effect such as:

  • nausea, upper stomach pain, itching, loss of appetite;
  • dark urine, clay-colored stools;
  • jaundice (yellowing of the skin or eyes); or
  • chest pain, trouble breathing.

Less serious side effects may include:

  • vomiting;
  • constipation;
  • feeling agitated;
  • headache; or
  • sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect acetaminophen injection?

Tell your doctor about all other medicines you use, especially:

  • an antibiotic, antifungal medicine, sulfa drug, or tuberculosis medicine;
  • a blood thinner such as warfarin (Coumadin, Jantoven);
  • birth control pills or hormone replacement therapy;
  • blood pressure medication;
  • cancer medications;
  • cholesterol-lowering medications such as Lipitor, Niaspan, Zocor, Vytorin, and others;
  • gout or arthritis medications (including gold injections);
  • HIV/AIDS medications;
  • medicines to treat psychiatric disorders;
  • an NSAID such as Advil, Aleve, Arthrotec, Cataflam, Celebrex, Indocin, Motrin, Naprosyn, Treximet, Voltaren, others; or
  • seizure medications.

This list is not complete and there may be other drugs that can interact with acetaminophen. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about acetaminophen.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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