A Randomized Phase III Trial of Accelerated Whole Breast Irradiation with Hypofractionation Plus Concurrent Boost versus Standard Whole Breast Irradiation Plus Sequential Boost for Early-Stage Breast Cancer
Stage I or II plus: <50 yrs old; or positive axillary nodes; or lymphovascular invasion; or more than 2 close resection margins (>0mm to =2 mm; or 1 close resection margin and extensive in-situ component; or focally positive resection margins; or ER and PR negative; or grade III histology; or oncotype recurrence score >25.
pStage 0 with nuclear grade 3 DCIS and patient <50 yrs old
ypStage 0, I or II resected by lumpectomy after neoadjuvant systemic chemotherapy
DCIS and >50 y/o, or nuclear grade 1 or 2 DCIS <50 y/o are inelgibile.
Treatment that includes regional node irradiation are inelgibile.